The series returns from its season three winter break on Tuesday, but an early description of season four provided to Deadline refers to the upcoming season as "game-changing."
The current storyline involves S.H.I.E.L.D.'s attempts to recruit Inhumans to their super-powered task force while facing down to forces of a resurgent HYDRA. The team will also contend with an alien entity posses the body of former agent Grant Ward.
Other series enjoying early renewal include comedies like The Goldbergs and Fresh Off the Boat and the new drama Quantico.