Based on the manga by Hiroaki Samura, the film will follow Manji, a ronin cursed with immortality. He also acts as bodyguard to a young woman who "swears vengeance against a group of sword fighters who murdered her parents."
Miike is known in the US for films like Audition and Ichi the Killer.
Blade of the Immortal is published in the US by Dark Horse Comics. ANN reports the company plans to reprint the series in an omnibus format.