Kevin Feige, head of Marvel Studios, said that it's possible for the Red Skull to show up in future Marvel movies. So will he be part of Captain America: Civil War? Even actor Hugo Weaving doesn't know.
"I have absolutely no idea," Weaving said when asked if he'd be returning for Captain America: Civil War or possibly in another Marvel film. "I haven't talked to anyone about it, so, yeah, we'll just have to wait and see. No idea at all."
In other interviews Weaving seems less than enthused to return to the franchise and there is some speculation that the mysterious villain that Daniel Bruhe will be playing may be a version of the Red Skull.