Giles the Watcher is based out of the Transmogrification Emporium instead of the school library.
Buffy The Vampire Slayer 25th Anniversary #1
Buffy Summers is not herself and, rather than Willow, is now Xander's lifelong friend since they were kids in Sunnydale.
Buffy The Vampire Slayer 25th Anniversary #1
And Xander Harris from the TV series, in retrospect seen[...]