Okay, Phil Coulson (Clark Gregg) is on a spaceship. It's hard to push that concept aside and think about other areas of Agents of S.H.I.E.L.D., but I'm going to try. The season finale showed us that Leo Fitz (Iain De Caestecker) is not going to be getting over what he did in the Framework any time soon. Even though we'll jump ahead some when the show comes back, executive producer Jed Whedon told EW.com:
"It's safe to say that he's not over it yet. Everybody now has some sort of pain, some sort of darkness in their past. We know how hard Fitz is on himself, and he was the worst kind of person in the Framework, so I don't think that's something you get over right away."
Marvel's Agents of S.H.I.E.L.D. will return in January 2018, after Marvel's Inhumans has its 8-episode run in September of this year.