There are some spoilers for Fantastic Beasts and Where to Find Them below, so be mindful!
Newt Scamander struck me as a strange character to hang a franchise on in Fantastic Beasts and Where to Find Them. Not because I disliked him, but more because he obviously enjoys being alone or with his animals, having a fair degree of social awkwardness that you wouldn't expect from a series protagonist.
However, it seems he likely isn't going to be the full focus of the series. Speaking to CinemaBlend, producer David Heyman confirmed that other characters might carry the torch in the film.
I don't think [Newt will be at] the heart of all of them. I think he'll be part — so will Tina, Queenie and Jacob — will be part of the next one.
Obviously, young Dumbledore is set to appear too, and Heyman confirms that Credence will be back too, so focus could go anywhere.
My guess is that the series will shift a little bit to focus more on the Dumbledore/Grindelwald relationship in the future, with the first film acting as a scene setter. I really am fascinated by the threads that have been left to explore. I can't wait to see where they lead.