Hugo Weaving hasn't been shy in the past to talk about his displeasure at playing the Red Skull in Captain America: The First Avenger. It has meant rumours about his return to the character have been muted.
However, it seems the door might have opened just a little bit on that. Speaking to Yahoo, in a series where he comments on films he has been in, it seems he has changed his tune a little saying he had a rather positive experience with the character:
It was fun to play; I enjoyed the outrageousness of the German accent that I employed and I enjoyed the extraordinary mask and costume, even though it was unbelievably hot inside it. I enjoy mask work; I enjoy trying to animate masks and reveal certain things that the mask itself might not reveal. V for Vendetta was another example of that, but there was less animation within that mask versus the Red Skull.
With Marvel, it's pretty basic stuff: accept the deal and enjoy the ride. It's not a major stretch for an actor, but on the other hand the difficulty with the Marvel universe is maintaining a link to a human dimension within such an extraordinary, technological CGI universe. In terms of me going back and doing another one, I don't know. I'm not sure what they're up to with the Red Skull.
Does this mean he could come back? Maybe. It's not any sort of confirmation, but it suggests it could happen, which brings us closer than we previously thought. With the character trapped inside a cosmic cube, and the Infinity War coming up, it doesn't seem impossible.