We've heard a lot about Uncharted 4 being the closer on the Nathan Drake story. It is being touted as 'the end' where it can be, and that has kept speculation as to the conclusion of the game swirling.
It seems it really might be the end for Nathan Drake too, at least according to co-director Neil Druckmann. Speaking to The Sun, Druckmann said that continuing to do the series after the conclusion for Uncharted 4 would be near impossible.
With the end of [A Thief's End's] story, it will be really hard to do a sequel with Nathan Drake. Maybe there'll be a prequel, maybe it will be a different character, I don't know. But this is the end for Nathan Drake.
Naughty Dog clearly want to end Drake on their terms, be that by death or by other means. I mean, death is the logical end the way the developer are talking about it, but I can't help shake the feeling that is just what they want us to believe. We'll find out in April I guess.