For my money, Vincent D'onofrio's Kingpin is the best villain in the MCU. Of course, I saw 'in the MCU', but we all know the Netflix-verse is a little to the side of the cinematic goings on. It's a shame too, as I'd love to see how he could really mess with certain members of the Avengers.
It looks like that pipedream is somewhere between a really long time away and never though. Speaking to Digital Spy, D'onofrio shut down hopes that he would ever turn up in a Marvel film. He said:
I would love to switch over to the movies, but I think it's pretty much been said it's not going to happen. Or at least not for a very, very long time. I think [Marvel Studios boss] Kevin Feige explained that, and that's what makes the most sense, he said the film universe is too jam-packed. It's hard enough already, and if they keep bringing big characters in that they have to service in the writing, it's not gonna work. They're trying to figure out already how to individualise more and at the same time keep The Avengers going. It makes sense not to mix the TV stuff, there's just too many characters.
This shouldn't be a massive surprise, as it is thought the TV and film divisions are somewhat separate entities of Marvel. Still, I'd love to see it. I think there is a ton of potential there.